Medicare local coverage
Medicare coverage for MolDX: Minimal Residual Disease Testing for Cancer (LCD)
4 Medicare Administrative Contractors publish a local coverage determination (LCD) for MolDX: Minimal Residual Disease Testing for Cancer. The snapshot lists 5 LCD records: 4 active, 1 retired.
An LCD applies only in the jurisdiction of the contractor that wrote it. Two contractors can cover the same service with different criteria, documentation requirements and covered diagnoses, so check the LCD from the contractor that processes your claims.
LCDs by contractor
| Contractor | LCD | Status | Last updated |
|---|---|---|---|
CGS Administrators, LLCMAC - Part A, MAC - Part B | L38822 | Active | Oct 31, 2025 |
Noridian Healthcare Solutions, LLCMAC - Part A, MAC - Part B | L38816 | Retired Feb 5, 2026 | Feb 5, 2026 |
Noridian Healthcare Solutions, LLCMAC - Part A, MAC - Part B | L38814 | Active | Jan 26, 2026 |
Palmetto GBAMAC - Part A, MAC - Part B | L38779 | Active | Nov 4, 2021 |
WPS Insurance CorporationMAC - Part A, MAC - Part B | L38835 | Active | Oct 21, 2025 |
An LCD marked Future has been finalized and is in its notice period; it applies from the effective date shown. LCD IDs link to the record on cms.gov.
CMS also lists 4 response-to-comments articles for this topic, where contractors answer public comments on the proposed LCD: A58915, A58916, A58953, A58954.
Check claim lines against Medicare coverage
Coverage Check tells you whether a claim's diagnoses support Medicare LCD or NCD coverage for each procedure line, and shows the policy and CMS source behind each answer.
Related LCD topics
- MolDX: Prostate Cancer Genomic Classifier Assay for Men with Localized Disease
- Endovascular Management for Peripheral Arterial Disease of the Upper and Lower Extremities
- Genetic Testing for Cardiovascular Disease
- Home Health Skilled Nursing Care-Teaching and Training: Alzheimer's Disease and Behavioral Disturbances
- Hospice - Liver Disease
- Hospice Alzheimer's Disease & Related Disorders
All Medicare LCD topics · National coverage determinations · Payer policies by payer
Source: CMS Medicare Coverage Database, via the public CMS Coverage API, snapshot Oct 25, 2026. LCDs change between snapshots; confirm the version in effect for your date of service on cms.gov before billing.